ITCW4 Agenda (PDF) | |
File Size: | 84 kb |
File Type: |
9:00 - 9:05 am
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Welcome and Opening Remarks
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9:05 - 9:25 am
9:25 - 9:45 am 9:45 – 10:05 am 10:05 – 10:35 am 10:35 - 11:00 am |
RESOLUTE: Accelerating research in Solute Carriers, SLCs, an untapped source of drug targets
Giulio Superti-Furga (Austrian Academy of Sciences) Precision medicine goes microscopic: interactions between the microbiome and intestinal drug transporters Peter Turnbaugh (UCSF) Genomewide Association Studies: Uncovering New Roles for Solute Carrier Transporters Kathy Giacomini (UCSF) Panel Discussion Break |
11:00 - 11:20 am
11:20 - 11:40 am 11:40 - 12:00 pm 12:00 - 12:30 pm |
Emerging importance of hepatic and renal OAT2: can we substantiate
clinical relevance in drug pharmacokinetics and DDIs? Hong Shen (Bristol-Myers Squibb) Folate transport pathways: What do we know of their roles in drug interactions and toxicity? Reina Bendayan (University of Toronto) Revisit of previous ITC recommendations on OATP2B1 and MRPs Maciej Zamek-Gliszczynski (GlaxoSmithKline) Panel Discussion |
12:30 - 1:00 pm
1:30 - 2:00 pm |
Poster Walk 1
Interactive Poster Q&A |
9:00 - 9:05 am
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Welcome and Opening Remarks
|
9:05 – 9:25 am
9:25 - 9:45 am 9:45 - 10:05 am 10:05 - 10:35 am 10:35 - 11:00 am |
Ontogeny of SLCO1B1 expression and function: Implications for statin disposition in children
J. Steven Leeder (Children’s Mercy Hospital, Kansas City) Transporter endogenous biomarkers in clinical drug development Kenta Yoshida (Genentech) Modelling of creatinine-drug interaction in chronic kidney disease population Aleksandra Galetin (University of Manchester) Panel Discussion Break |
11:00 - 11:30 am
11:30 - 12:00 pm 12:00 - 12:30 pm |
A regulatory perspective for transporter-mediated DDIs: current status and challenges
Xinning Yang (US FDA) Transporter-mediated drug drug interactions - European regulatory perspectives Carolien Versantvoort (Medicines Evaluation Board, The Netherlands) Panel Discussion to include ITC Members |
12:30 - 1:30 pm
1:30 - 2:00 pm |
Poster Walk 2
Interactive Poster Q&A |
9:00 - 9:05 am
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Welcome and Opening Remarks
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9:05 - 9:15 am
9:15 - 9:25 am 9:25 - 9:25 am 9:35 – 10:05 am 10:05 - 10:30 am |
Transcriptional and post-transcriptional regulation of organic anion transporting polypeptides
Henriette E. Meyer zu Schwabedissen (University of Basel) Post-translational regulation of OATP1B1 and OATP1B3: Association with clinically significant polymorphism and implications in drug-drug interactions Wei Yue (University of Oklahoma Health Sciences Center) Transcriptional and post-transcriptional regulation of transporters in the human intestine Stefan Oswald (Rostock University Medical Center) Panel Discussion Break |
10:30 - 10:40 am
10:40 - 10:50 am 10:50 - 11:00 am 11:00 - 11:30 am |
Overview of metal/metalloid transporters and toxicity
Elaine Leslie (University of Alberta) Solute carriers and chemotherapeutic induced toxicity Alex Sparreboom (Ohio State) Placental transport and environmental chemical exposures Lauren Aleksunes (Rutgers) Panel Discussion |
11:30 - 11:40 am
11:40 - 11:50 am 11:50 - 12:00 pm 12:00 - 12:30 pm |
CRISPR/Cas9 models for drug transporters
Per Artursson (Uppsala University) Intravital microscopy for studying transport processes – potential and limitations Kenneth Dunn (Indiana University) Dissecting transport barriers in cancer using intravital microscopy of single-cell pharmacology Miles Miller (Harvard Medical School) Panel Discussion |
12:30 - 1:30 pm
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Breakout Sessions for Whitepapers
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Name |
Affiliation |
Kim Brouwer |
University of North Carolina at Chapel Hill |
Aleksandra Galetin |
University of Manchester |
Kathy Giacomini |
University of California San Francisco |
Mike Hafey |
Merck and Co |
Shiew-Mei Huang |
U.S. Food and Drug Administration |
Lawrence Lin |
University of California San Francisco |
Par Matsson |
University of Gothenburg |
Donald Tweedie |
Independent |
Xinning Yang |
U.S. Food and Drug Administration |
Kenta Yoshida |
Genentech |
Wei Yue |
University of Oklahoma |
Maciej Zamek-Gliszczynski |
GlaxoSmithKline |
Lei Zhang |
Silver Spring, MD |